Metabolic Control Analysis(MCA) Essay -- Science Biochemistry

Metabolic Control Analysis(MCA) Essay -- Science Biochemistry

Introduction: In 1970s, a new method called (Metabolic Control Analysis) for analysing the distribution control of the flows and medium concentrations in the metabolic path between different enzymes that form the corridor, was developed by Henrik Kacser and other scientists. Since then, attention was paid to more research in this method and its applications, and developing analytical and educational tools (Wildermuth, 2000). In the flowing literature review, some examples of the significance of Metabolic Control Analysis, pros and cons will be discussed. Literature review: At first glance, engineering a metabolic system with aim of raising metabolite's yield or flux during a metabolic pathway system, could be done through the method of identifying and controlling, which called rate-limiting-steps. Rate-limiting steps is a certain steps in the paths that exercising the most control over the whole system.